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In , Paul di Sant'Agnese discovered abnormalities in sweat electrolytes; a sweat test was developed and improved over the next decade. Sodium is the most common cation in the extracellular space. American Journal of Epidemiology. Acute lymphoblastic leukemia Lymphoma. Journal of Cystic Fibrosis. However, the best dosage and form of pancreatic enzyme replacement is unclear, as are the risks and long-term effectiveness of this treatment. There is no strong evidence that people with cystic fibrosis can prevent osteoporosis by increasing their intake of vitamin D.

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