Since this enzyme is the rate limiting factor for purine synthesis,  this alters the synthesis and function of RNA and DNA. Dihydrofolate reductase inhibitor Aminopterin Methotrexate Pemetrexed Pralatrexate Thymidylate synthase inhibitor Raltitrexed Pemetrexed. Journal of Cancer Research and Clinical Oncology. Other more serious side effects include black or tarry stools melena , bloody stools, and bloody urine. Ribonucleotide reductase inhibitor Hydroxycarbamide.
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